Bioidentical Hormone Training Optimization & Testing (Female, Male, Thyroid, Adrenal)

BHRT Training Course CME Accredited for MD, DO, PA, NP and RN’s. 

Fully Streaming Online
Updated course is streaming NOW: All New 12 Hours CME AMA or ANCC plus 7.0 Pharmacotherapeutic Hours effective 10/1/26.  180+ Clickable links to the primary literature or regulatory bodies.  Reserve your course now and begin watching the 2027 version today!

Since 2008, PracticalCME’s Bioidentical Hormone PracticalCME offers Botox Training, Dermal Filler Certification and other aesthetic training courses taught only by MD's in small group settings. Training for physicians, and nurse practitioners are built for providers who want to elevate their skillset and begin diagnosing and treating key hormone imbalances immediately. Specifically, precise saliva testing is used for male, female and adrenal body clock testing with accurate T3 and T4 levels for thyroid panels. In particular, only Board-Certified experienced MD physicians teach our classes.  This class has been revised and updated dozens of times since its debut in 2008.  This latest version is the most supported one yet with 180+ live links to primary sources to support what we teach.  This is the perfect training to pair with any weight loss program as these hormonal imbalances serve as the headwinds for any successful diet even when using GLP-1’s.  As always with PracticalCME, there are NO SPONSORS controlling the curriculum and no recommendation of fad products or Multi-Level Marketing Supplements.

Fully CME-Accredited Online Bioidentical Hormone Certification Course

Moreover, the presentation is backed by the support of  peer-reviewed literature sources.  Upon completion of the online post-test, attendees can download and print their Accredited CME certificate worth 12 AMA PRA Category 1 Credits for physicians and PA’s or 12 ANCC Contact Hours plus 7.0 Pharmacotherapeutic Hours.  Stream the course at your own pace.  Since the field is always changing, this is the only course that pushes free updates to all registered users for 2 years after purchase.  Finally, our expert MD faculty are always available by email, phone or live online chat with any questions you might have during the training process or while implementing your new service.

🛒REGISTER NOW: Bioidentical Hormone CME Training and Wellness Certification Packages

Modern Bioidentical Hormone Optimization & Testing (Female, Male, Thyroid, Adrenal)

Detailed Course Outline · Version 15 ·  Released October 1, 2026

Accreditation: This activity is approved for 12.0 hours ACCME / AMA PRA Category 1 Credit™, with AAPA reciprocity for physician assistants, and 12.0 ANCC contact hours (including 7.0 pharmacotherapeutic hours) for nurses and nurse practitioners. Credit term October 1, 2026 through October 1, 2028

Format & depth: Online enduring material · approximately 12.5 hours of instruction across eight sections and 292 slides, covering female, male, thyroid, and adrenal hormone evaluation and treatment.

Evidence base: 170+ unique primary references are linked directly inside the slides, including peer-reviewed literature, specialty society guidelines, FDA actions, and approved drug labels. Reference counts are listed section by section below.

1. Foundations: Bioidentical Medicine, Stress, and the Standard of Care ~45 min 2 references

  • What bioidentical actually means: the three criteria of substance, dose, and duration
  • Why patient demand is so high, and what the stress literature does and does not support
  • Physiology versus pharmacology, and disease versus treatable entity
  • Common versus normal, and the standard of care: meeting it versus exceeding it
  • Documenting off-label use and informed consent as a practice standard
  • Where peptides fit in a bioidentical practice, and where they do not

2. Diagnosing and Treating Female Hormone Imbalance ~165 min 46 references

  • Menstrual cycle and menopause transition physiology, including why a single FSH does not diagnose the transition
  • Natural roles of estrogens, progesterone, and testosterone in women, plus estrogen metabolism and toxic metabolites
  • Estrogen dominance as a relative progesterone deficiency, and xenoestrogen exposure that no panel can measure
  • The problems with pharmaceutical HRT: synthetic progestins versus micronized progesterone, oral versus transdermal route, hepatic first pass, WHI and its 20-year follow-up, and the 2025 removal of the boxed warnings
  • FDA-approved and compounded options: patches, gels, injections, vaginal preparations, BiEst ratios, and compounded vaginal estriol under Section 503A
  • PMS and cyclic symptoms: cyclic progesterone protocols, heavy and irregular bleeding, menstrual migraine, and when endometrial sampling is required
  • Endometrial protection: when oral progesterone is mandatory, the limits of transdermal progesterone, and why saliva cannot serve as the safety monitor
  • Testosterone in women: causes of deficiency, dosing, monitoring, the 2019 Global Consensus position, and the side effects that may not reverse

3. Diagnosing and Treating Male Hormone Imbalance ~75 min 27 references

  • Testosterone physiology and metabolism, including DHT and the adipose-estrogen loop
  • Effects of obesity, stress, sleep debt, and illness on testosterone production
  • History and regulation of testosterone therapy, through the Anabolic Steroid Control Acts and the February 2025 FDA class-wide labeling changes
  • Outcomes evidence: mortality data, the T Trials, TRAVERSE, depression, and prostate cancer
  • Libido, erectile dysfunction, and andropause as a symptom complex rather than a number
  • FDA-approved injections, oral products, and gels, their drawbacks, and compounded transdermal dosing
  • Contraindications, fertility counseling before the first prescription, and monitoring of hematocrit, PSA, and blood pressure
  • Aromatase inhibition and why blocking estradiol conversion is not recommended, and why pellets are not bioidentical

4. Principles of Salivary Hormone Testing ~45 min 21 references

  • How laboratory reference intervals are actually constructed, and why they are not outcome based
  • Narrower functional ranges: what they support and what they cannot claim
  • Total, free, and bioavailable fractions, plus the binding proteins that shift them
  • Blood versus saliva versus urine, including which free testosterone methods are unacceptable
  • Published support for salivary cortisol and sex steroid measurement, and where saliva is not valid
  • Collection technique, hormone pulsatility, and choosing and staying with one laboratory

5. Bioidentical Thyroid Testing and Treatment ~105 min 46 references

  • Thyroid physiology, hormone production, and peripheral conversion
  • The symptoms and signs that actually discriminate for tissue hypothyroidism, using a validated clinical score
  • Drugs, toxins, non-thyroidal illness, and biotin interference in thyroid testing
  • TSH interpretation, treatment thresholds, subclinical hypothyroidism, Hashimoto’s, and pregnancy
  • Levothyroxine products, potency specification, and generic substitution, plus liothyronine and desiccated thyroid, including current regulatory status
  • Combination T4 and T3 therapy: the evidence and the 2021 consensus criteria
  • Starting doses, titration, monitoring intervals, and long-term safety in patients over 65

6. Testing and Treating Stress-Induced Adrenal Dysfunction ~135 min 41 references

  • Adrenal anatomy, the steroid pathway, and measured daily cortisol and DHEA production
  • The daily cortisol rhythm and the cortisol awakening response
  • Cushing’s and Addison’s disease: the features that discriminate, first-line testing, and when to refer
  • 4-point salivary cortisol collection technique and the six curve shapes
  • Literature review of stress physiology, including the published critique of adrenal fatigue as a diagnosis
  • DHEA replacement, plus first-line vitamin, phosphatidylserine, theanine, magnesium, and melatonin therapy
  • Second-line therapy: ashwagandha for elevated cortisol, and low-dose hydrocortisone for low cortisol with consent, dose ceilings, a retest, and a documented exit plan
  • Licorice and adrenal glandulars: mechanism, product contamination data, and why they are taught but not recommended

7. Confounding Factors and Additional Stressors ~30 min 11 references

  • Lifestyle stressors: sleep, menu, activity, caffeine, and morning light exposure
  • Medication stressors: steroids by every route, opioids, progestins, and stimulants, plus assay interference
  • Chronic disease, gut health, and the limits of what elimination diets demonstrate
  • Weight expectation counseling, fasting and cortisol, and where GLP-1 drugs fit
  • Peptides and bioidentical medicine: what is approved, what may be compounded, and what is marketing

8. Practice Implementation and Case Studies ~120 min 5 references

  • Implementing the service: patient selection, advertising, staff scripts, and professional boundaries
  • Using supplements judiciously, applying AMA Code of Medical Ethics Opinion 9.6.4
  • New patient history and visit structure, the first-visit lifestyle assignment, and coding and time documentation
  • Starting dose and monitoring summaries for female, male, thyroid, and adrenal treatment
  • Basic case studies: interpreting panels and formulating an initial treatment plan
  • Advanced case studies: patients overdosed by other providers, pellet patients, oral estrogen conversions, and single-sample interpretation
  • Reacting to initial symptom recovery, choosing retest intervals, and knowing when to stop treatment

Where the Citations Come From

Clinical claims in this course are linked to primary sources and to current professional society guidance, on the slide where the claim is made rather than in a bibliography at the end.

  • Guidelines and societies — American Thyroid Association · Endocrine Society · ACOG · The Menopause Society · British Menopause Society · European Menopause and Andropause Society · AACE · American Medical Association
  • Journals — JCEM · The Lancet · New England Journal of Medicine · BMJ · Annals of Internal Medicine · Mayo Clinic Proceedings · Climacteric · Maturitas · Molecular and Cellular Endocrinology · Journal of Human Hypertension · Psychological Bulletin · Stress · Cochrane Database of Systematic Reviews
  • Regulatory and primary documents — FDA drug labeling and safety communications · FDA compounding guidance and bulk drug substance lists · Federal Register notices · USP monographs · GAO reports · DEA and HHS prescribing rules · manufacturer package inserts

Modern Bio-Identical Hormone Optimization and Testing (Female, Male, Thyroid, Adrenal)

This course is approved for 12.0 ACCME, AMA Category 1, or 12.0 ANCC credit hours with 7.0 pharmacotherapeutic hours for Nurses and Nurse Practitioners.

Accreditation dates:  October 1, 2026 through October 1, 2028

Joint Accreditation Statement

In support of improving patient care, this Jointly accredited CME approval logo activity has been planned and implemented by and Practical CME. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare
team.
Amedco Joint Accreditation Provider Number: 4008163
Professions in scope for this activity are listed below.

Physicians

Amedco LLC designates this material for a maximum of 12.0 AMA PRA Category 1 Credits for physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses

Amedco LLC designates this activity for a maximum of 12.0 ANCC contact hours including 7.0 pharmacotherapeutic hours.

Watch our PracticalCME Bioidentical Hormone Certification Training Overview Video...

Eligibility for Training…
  • Doctors (MD’s and DO’s)
  • Nurse Practitioners
  • Physician Assistants
  • Registered Nurses
  • Naturopathic MD’s

Other providers can take the course and receive the certificate, but legal scope of practice in your location is determined by your licensure, not a single training course.

First, Reserve your Online Training Seat in Evidence-Based Weight Loss or Bundle with Saliva Testing/BHRT and/or Neurotransmitter/GI training.

You will have 2 Years of Unlimited Online Access wtih Free Updates pushed to your account periodically as needed and new drugs are approved.

online-video-cme-courses

Then Watch the Online training at your own pace.  Follow clickable links and interact with our faculty for any questions you have.  When finished, complete the online post-test.

DOWNLOAD/PRINT CME CERTIFICATE

No training course alters the legal scope of practice as defined by the medical/nursing boards in your home state/country. Please review all state/country requirements for supervision for these procedures prior to adding them to your practice.

BHRT as the Foundation for Modern Wellness Practice

Peptide therapy is one of the fastest-growing areas of interest in functional and regenerative medicine, but peptides do not replace hormone optimization. They work alongside it. Compounds like sermorelin, ipamorelin, CJC-1295, and BPC-157 modulate growth hormone, tissue repair, and recovery pathways, but their effectiveness depends on a properly balanced endocrine baseline. Providers who prescribe peptides without first assessing testosterone, estrogen, thyroid, and cortisol levels are working are trying to build on top of an uncertain foundation.

This BHRT certification course gives you the hormone testing and prescribing foundation that responsible peptide practice requires. Once you understand salivary hormone assessment, adrenal fatigue, thyroid optimization, and BHRT protocols for male and female patients, you have the diagnostic framework needed to evaluate whether peptide therapy is appropriate, safe, and effective for any given patient — and to monitor results objectively rather than by symptom alone.

Why Hormone Balancing Should Come Before Peptides

  • Growth hormone peptides (sermorelin, ipamorelin, CJC-1295) work downstream of thyroid and cortisol — untreated hypothyroidism or adrenal dysfunction will blunt peptide response.
  • BPC-157 and tissue repair peptides are commonly prescribed for recovery, but chronic cortisol elevation (assessable via saliva testing) impairs the healing they’re meant to accelerate.
  • Sexual function peptides like PT-141 are often prescribed for symptoms that originate in untreated testosterone or estrogen imbalances — issues that BHRT addresses at the source.
  • Patient safety requires baseline hormone testing before introducing any modulating compound. Peptides without hormone testing is the same mistake as prescribing antidepressants without checking thyroid.
  • Insurance and regulatory environment for peptides remains unsettled. BHRT is established, accredited, and defensible — a stable practice revenue line that complements peptide offerings without depending on them.

Frequently Asked Questions: BHRT Certification Training Course


About the Course

Is this BHRT training course CME accredited?

Yes. This bioidentical hormone replacement therapy training is accredited continuing medical education. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

How many CME credits does the BHRT course provide?

The course provides 12.0 AMA PRA Category 1 Credits™ or 12.0 ANCC contact hours, including 7.0 pharmacotherapeutic hours. Credit is claimed after completing the post-test, and your certificate is available to download and print immediately.

Who is this bioidentical hormone training course for?

The course is written for licensed prescribers and clinical staff who want to evaluate and treat hormone imbalance in their own practice: MD, DO, PA, NP and RN. It assumes clinical training but no prior experience with bioidentical hormone therapy or saliva hormone testing.

Do nurse practitioners and physician assistants receive credit?

Yes. Nurse practitioners and registered nurses may claim ANCC contact hours, and physician assistants may claim AMA PRA Category 1 Credit™, which the NCCPA accepts. 

Do I receive a BHRT certification or a certificate of completion?

You receive an accredited CME certificate documenting completion of the activity and the credits earned. BHRT is not a recognized medical specialty and no organization confers board certification in it, so no course, including this one, can grant a specialty credential. What the certificate documents is verifiable accredited education in hormone optimization and testing.

Is this a live course or self-paced online training?

It is entirely self-paced streaming video. There is no live attendance requirement, no scheduled session and no travel. You can start, stop and revisit any module, and most learners complete it across several sittings rather than in one.

How long do I have access to the BHRT course?

Enrollment includes two years of unlimited access. Updates published during your access term are included at no additional cost, which matters in a field where drug labeling and regulatory guidance change frequently.

Do I need prior hormone therapy training to take this course?

No. The course begins with definitions, regulatory structure and testing methodology before any treatment is discussed, so a clinician new to bioidentical hormone therapy can follow it from the first section. Experienced prescribers generally find the adrenal and thyroid modules the most substantive.

What does the BHRT certification course cost?

The course is $1,295, which includes all eight sections, the case series, the downloadable clinical reference tools, the post-test and the accredited CME certificate, with two years of access and free updates as they are released.

Is there a post-test?

Yes. A post-test follows the curriculum and must be completed to claim credit. It is drawn directly from the material taught, and you may review any module before taking it.

What is included with enrollment?

Eight streaming online sections covering female, male, thyroid and adrenal hormone optimization; a worked case series; downloadable clinical references including a printable syllabus, and a desiccated thyroid conversion table; the post-test; and your accredited CME certificate.

How is this edition different from the previous version of the course?

Every section was rewritten against the current literature and the current regulatory landscape. Clinical claims now carry linked citations on the slide where the claim is made. Several positions taught previously have been revised or removed, and those changes are identified explicitly with the source that prompted them. The adrenal and thyroid modules in particular bear little resemblance to the prior edition.


What the Course Covers

Does the course cover female hormone therapy and menopause?

Yes. Section 2 covers female hormone physiology, perimenopause and menopause, estrogen replacement therapy and delivery routes, progesterone therapy and endometrial protection, the cycling patient with cyclic symptoms, genitourinary syndrome of menopause and vaginal atrophy, and testosterone therapy in women.

Does the course cover testosterone replacement therapy in men?

Yes. Section 3 covers diagnosing low testosterone and male hypogonadism, the contraindications that should stop you from prescribing, delivery routes and transfer precautions, current FDA labeling, hematocrit and PSA monitoring schedules with the specific numbers that trigger referral, and the prescribing and telemedicine rules that apply to a Schedule III medication.

Does the course cover thyroid diagnosis and treatment?

Yes. Section 4 covers thyroid physiology and lab interpretation, the signs and symptoms that actually discriminate hypothyroidism, treatment thresholds and how to defend them, pregnancy and preconception, levothyroxine and liothyronine dosing, T4 and T3 combination therapy, and desiccated thyroid including its content, its current regulatory status and full conversion arithmetic.

Does the course cover adrenal function and cortisol testing?

Yes, extensively. Section 5 is the longest in the course and covers adrenal anatomy and HPA axis physiology, cortisol production and DHEA, Cushing’s and Addison’s as the diagnostic boundaries, the adrenal fatigue controversy examined in full including the critical literature, four-point saliva cortisol testing, cortisol curve pattern interpretation, medications that distort the curve, and treatment in sequence from lifestyle through vitamins, herbals, DHEA and hydrocortisone.

Does the course teach saliva hormone testing?

Yes. Saliva hormone testing is taught throughout rather than as a separate topic: collection technique, the errors that manufacture a false result, what saliva measures that serum does not, where salivary measurement is well supported and where it is not, and how to interpret a four-point cortisol curve by shape rather than by individual values.

Does the course cover compounded hormones and FDA regulation?

Yes. Section 1 covers the regulatory architecture in detail: FDA-approved products versus compounded preparations, Section 503A eligibility, USP monographs and bulk drug substance lists, marketed unapproved drugs, off-label prescribing, and how to evaluate a compounding pharmacy and read a certificate of analysis.

Does the course cover coding, documentation and compliance?

Yes. Section 7 covers the new patient visit and intake history, setting expectations, the follow-up visit, coding office visits correctly under current CPT rules, advertising limits, staff scripting, the ethics of dispensing supplements in the office, and documenting off-label use and informed consent.

Are real patient cases included?

Yes. Section 8 presents de-identified cases drawn from clinical practice across gonadal, thyroid and adrenal systems in both sexes and across age ranges, with the testing and reasoning shown as they occurred, including cases where the initial impression was wrong and cases that did not respond.


About Bioidentical Hormone Therapy and Testing

What is bioidentical hormone replacement therapy (BHRT)?

Bioidentical hormone replacement therapy uses hormones that are structurally identical to those the human body produces, such as estradiol, progesterone and testosterone, to replace hormone levels that have declined or become dysregulated. The term describes the molecule, not the source and not the manufacturing route: a bioidentical hormone may be FDA-approved or compounded.

What conditions is bioidentical hormone therapy used for?

BHRT is used in the management of menopausal and perimenopausal symptoms, andropause and symptomatic low testosterone in men, cyclic menstrual symptoms, hypothyroidism, and disturbances of the cortisol rhythm including sleep and body clock complaints. Appropriate use depends on testing, diagnosis and the clinical picture rather than symptoms alone.

Are bioidentical hormones the same as natural hormones?

“Bioidentical” means the molecule is identical to the one the body makes. It does not mean natural, and the two words are frequently confused in marketing. Many bioidentical hormones are synthesized in a laboratory, and many plant-derived preparations are not bioidentical at all. The course spends its first module untangling exactly this.

Are bioidentical hormones safer or more effective than synthetic hormones?

That claim is made frequently and it is not established. Head-to-head outcome data comparing bioidentical and synthetic preparations are limited, and the FDA has specifically cautioned against marketing compounded hormones as safer or more effective. What can be said is that some bioidentical preparations have different receptor and metabolic behavior than some synthetics, and that the course teaches you to describe those differences accurately rather than to overstate them.

What are the risks of bioidentical hormone therapy?

The same risks that apply to any hormone therapy apply here, and they are real. They include endometrial risk when estrogen is given without adequate progestogen protection, thromboembolic and cardiovascular considerations, contraindications in patients with a history of hormone-sensitive cancer, erythrocytosis and prostate monitoring obligations in men, suppression of fertility with exogenous testosterone, and virilizing effects that may not reverse. A substantial portion of the course is devoted to screening for these before the first prescription and monitoring for them afterward.

What is salivary hormone testing?

Salivary hormone testing measures the unbound, biologically available fraction of a hormone that has left the circulation and entered tissue, using saliva collected by the patient at specified times. Because saliva reflects free rather than protein-bound hormone, the result is not affected by changes in binding globulins the way a total serum level is.

Is saliva hormone testing accurate?

It depends on which hormone and which question. Salivary cortisol is well established and is the standard method for assessing the cortisol rhythm across the day, which a single blood draw cannot do. Salivary measurement of sex steroids is more variable and is not endorsed for every purpose by every professional body. The course teaches where salivary testing is well supported, where it is not, and how collection technique itself can create a false result.

Which hormones can be measured in saliva?

Cortisol, DHEA, estradiol, estriol, progesterone, testosterone and melatonin are commonly measured in saliva. The four-point cortisol curve, collected across a single day, is the measurement the adrenal module is built around.

Does insurance cover BHRT or saliva hormone testing?

Coverage varies widely by payer, by hormone and by indication, and saliva hormone panels are frequently not covered. The course addresses how to discuss cost with patients in advance, and how to code the office visit itself correctly, which is a separate question from whether the testing is reimbursed.


Getting Started

How do I enroll in the BHRT training course?

Order the course online. You will receive an email with your login credentials, and the full curriculum is available immediately. There is no waiting period and no application.

Can I start the course and finish it later?

Yes. Progress is saved, and you have two years of access. Most learners work through it over several weeks rather than in a single sitting, and many return to specific modules as clinical questions come up in practice.

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